Primary amine groups can be used to link various modification groups to oligonucleotides. Amino modifications can be placed at the 5' end, usually including C6 or C12; or amino modifications may be positioned at the 3' end, usually including C7, etc. Oligonucleotides linked to primary amines can be coupled with the remaining other types of molecules, so as to expand the application range of oligonucleotide drugs.

Suzhou Olipharma provides a variety of common oligonucleotides coupling products, which can be bound with SMCC, PEG-Azides, Peptide, etc., and also offers various GalNac modified oligonucleotides, such as L96, NAG37.