ASO
Antisense oligonucleotides (ASOs) are single-stranded oligonucleotides molecules with 15-25 nucleotides in length. After entering the cell, ASOs are bound to their respective complementary target mRNAs under the action of ribonuclease H1 (Rnase H1) upon the principle of complementary base pairing, which inhibits the expression of target genes.
Phosphate backbone modification: Oxygen atoms in ASO phosphate groups are replaced by sulfur atoms to form a phosphorothioate (PS) backbone.
Sugar ring 2' position modification: the most commonly used types of ASO modification are 2′-O-methylation (2'-O-Me) and 2′-O-methoxyethyl (2'-MOE).
Suzhou Olipharma has established a production platform having passed the ISO 9001 quality management certification, and has a standard production process, thereby being capable to provide customers with ASO products modified with different PS backbones and sugar rings. Adopting advanced technologies of synthesis and purification, as well as rigorous testing standards, the Company can provide customers with superior products.
Figure Commonly Used Monomer Types of ASO
